Whitlock's perfect start to the season continued as he pounced on eight missed doubles from Rob Cross on his way to a heavy 7-1 win over the World Champion.
Three misses from Cross in leg one allowed Whitlock in for an immediate break of throw, before the Australian was fiven a let-off for misses in two visits before he doubled his lead on double two.
Cross finished 72 on double six to claim leg three, but paid for three further misses in leg five and two missed doubles in the seven as Whitlock moved 6-1 up, before the former European Champion took out 106 to seal the win.
Smith, meanwhile, continued his winning start to the Unibet Premier League season with a 7-4 defeat of Daryl Gurney, following up last week's comeback victory over Gary Anderson with another strong display.
The former World Youth Champion raced into a 3-0 lead, finishing 70 and 72 either side of a superb 124 bull finish for a 12-darter to break throw in leg two.
Gurney hit back to level with three in a row of his own, and was locked at four-all before Smith followed up tops by punishing four missed doubles from the World Grand Prix champion to break and move 6-4 up.
Gurney landed another 180 in leg 11, but missed the bull to force a decider and Smith took out 64 to claim another two points.
"Last week was a struggle against Gary but I'm over the moon with this win," said Smith, who also won a UK Open Qualifier on Sunday.
"To get two wins out of two is unbelievable and to be on four points after two weeks is great.
"After playing so well at the weekend I wanted to come here and play well too. I could have made it a bit easier but I could have lost too, so I'm happy to win
PETER WRIGHT claimed his first Unibet Premier League win over Michael van Gerwen with a 7-5 win over the reigning champion in Cardiff on Thursday, as Simon Whitlock and Michael Smith claimed their second wins of the season.
World number two Wright had missed six darts to defeat Van Gerwen in last year's Premier League final, but this time held his nerve to close out victory and pick up his first win of the season.
After double 12 gave Van Gerwen the opener, Wright claimed the next three - twice punishing missed doubles from the Dutchman - to take command before the reigning champion took out 76 and 65 to level after six legs.
Wright took out 116 to regain the lead before a 13-darter moved him 5-3 up, with Van Gerwen responding with a magnificent 170 checkout only to see a 96 finish featuring two doubles to put the UK Open champion 6-4 up.
A missed match dart from Wright allowed Van Gerwen back in to force a deciding leg, but a 180 came in vain as the Scot took out tops for another 13-darter to complete the win.